李佳真推薦直播開箱

身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。

這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。

評比標準與整理方向

這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。

評分項目	滿分5分	評比重點
環境氛圍	⭐⭐⭐⭐⭐	用餐空間是否舒適、有設計感、適合聚會或約會
口味表現	⭐⭐⭐⭐⭐	餐點是否新鮮、調味平衡、有無記憶點
CP值	⭐⭐⭐⭐⭐	價位與份量是否合理，是否值得回訪
再訪意願	⭐⭐⭐⭐⭐	整體體驗是否令人想再來、服務是否加分

整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。

10間臺中公益路餐廳評比懶人包

公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。

餐廳名稱	料理類型	價位範圍（每人）	推薦菜色	適合族群	我的評價摘要
1️⃣ 一頭牛日式燒肉	和牛燒肉	$1200~$1400	A5和牛拼盤、 旬味野炊飯	情侶慶祝、燒肉愛好者	肉質頂級、陶瓷烤爐，沒有用木炭
2️⃣ TANG Zhan 湯棧	火鍋 / 麻香鍋	$500–$800	麻香鍋、麻油雞鍋	情侶、朋友、文青聚會	文青風火鍋代表，湯底濃郁卻不膩、環境質感佳
3️⃣ NINI 尼尼臺中店	義式料理 / 早午餐	$400–$700	松露燉飯、薄餅披薩	姊妹聚會、家庭聚餐	採光好、氣氛輕鬆，餐點份量實在
4️⃣ 加分100%浜中特選昆布鍋物	北海道鍋物	$400–$700	牛奶昆布鍋、海鮮拼盤	家庭聚餐、親子用餐	湯底細緻清爽、CP值高、服務親切
5️⃣ 印月餐廳	中式創意料理 / 宴會餐廳	$800–$1500	松露雞湯、蒜香牛肋條	商務宴客、家庭聚餐	菜色融合創意與傳統，氣氛高雅
6️⃣ KoDō 和牛燒肉	高檔日式燒肉	$1200–$2000	冷藏肋眼、壽喜燒套餐	節慶慶祝、燒肉控	儀式感十足、肉質極佳、服務細膩
7️⃣ 永心鳳茶	臺式茶館 / 早午餐	$300–$500	炸雞腿飯、鳳茶甜點	姊妹下午茶、親子餐聚	茶香融入料理，氛圍優雅放鬆
8️⃣ 三希樓	江浙菜 / 港點	$600–$900	小籠包、東坡肉	家庭聚餐、長輩慶生	火候精準、味道穩定，傳統中菜代表
9️⃣ 一笈壽司	日式壽司 / 無菜單料理	$1000–$1500	握壽司套餐、生魚片	日料控、紀念日用餐	食材新鮮、主廚手藝細膩，私密高雅
🔟 茶六燒肉堂	和牛燒肉 / 精緻套餐	$700–$1000	厚切牛舌、和牛拼盤	家庭、情侶、朋友聚餐	品質穩定、氣氛熱絡，年輕族群最愛

一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選

 

走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。

餐點特色

一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。
嚴選的和牛部位，共八個部位、十樣餐點，讓人能從牛頭一路品嘗到牛尾。
油花分布均勻、切片厚薄恰好，經過炭火烤炙後香氣四溢，焦香與油脂在口中交融，入口即化的滑順感令人難忘。
值得一提的是，一頭牛的菜單設計十分彈性
想要一次體驗完整套餐也可以，偏好客製口味則能自由單點組合，不受套餐限制，想吃什麼就點什麼。
而且每桌都能選擇「自行燒烤」或「專人代烤」服務，烤肉管家的火侯掌握與節奏讓整體體驗更輕鬆愉快。
除了主角和牛，旬味野炊飯 與 主廚冰淇淋 也是隱藏版亮點，前者粒粒分明、香氣撲鼻；後者以香草與焙茶為基底，隨季節更換口味，完美收尾。整體服務親切熱情，特別是壽星還能享有 生日畫盤驚喜，讓慶祝時刻更添儀式感。

用餐體驗

整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。
如果是第一次約會或慶祝特別節日，這裡的氛圍既不尷尬又不吵鬧，是營造氣氛的理想選擇。

綜合評分

評分項目	分數（滿分5分）	評語
環境氛圍	⭐⭐⭐⭐⭐	光線柔和、氣氛沉穩，極具日式質感
口味表現	⭐⭐⭐⭐⭐	A5和牛入口即化、炭香迷人
CP值	⭐⭐⭐⭐	價格略高但品質與服務對得起價位
再訪意願	⭐⭐⭐⭐⭐	適合慶祝、約會，一吃就難忘的燒肉店

地址：408臺中市南屯區公益路二段162號

電話：04-23206800

官網：http://www.marihuana.com.tw/yakiniku/index.html

小結語

一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。
若要在公益路找一間能讓人「邊吃邊微笑」的燒肉店，一頭牛 絕對值得列入你的必訪清單。

TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重

在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。
黑灰調的現代外觀、搭配微霧玻璃與招牌的「湯棧」燈字，呈現出一種低調的時尚感。
店內設計延續品牌主題，以「湯」為靈魂打造整體體驗，從裝潢到香氣，都有濃厚的溫潤氣息。

餐點特色

湯棧最有名的當然是它的「麻香鍋」。
湯底以雞骨與多種辛香料慢熬，香氣濃郁卻不嗆辣，入口後會在喉間留下柔和的花椒香。
「招牌麻油雞鍋」與「黃金牛奶鍋」也是人氣選項，特別是在冬天，溫潤的湯底配上滑嫩肉片，讓人每一口都覺得暖心。
他們的「滷肉飯」和「香蔥豆腐皮」更是許多老客人必點的靈魂配角，簡單卻有記憶點。

用餐體驗

整體氛圍比一般火鍋店更有質感。
桌距寬敞、燈光柔和，店員動作俐落又親切。即使客滿，也不會感覺吵雜或壓迫。
不論是一個人想靜靜吃鍋、或是朋友聚餐，湯棧都能給你剛剛好的距離與溫度。
值得一提的是，上菜速度快、湯底續湯毫不手軟，細節服務到位。

綜合評分

評分項目	分數（滿分5分）	評語
環境氛圍	⭐⭐⭐⭐⭐	文青感強、光線柔和，是拍照好選擇
口味表現	⭐⭐⭐⭐☆	麻香濃郁、湯頭層次豐富、不油不膩
CP值	⭐⭐⭐⭐	份量足、價格中等偏上
再訪意願	⭐⭐⭐⭐⭐	冬天或雨天時會特別想再訪的火鍋店

地址：408臺中市南屯區公益路二段248號

電話：04-22580617

官網：https://www.facebook.com/TangZhan.tw/

小結語

TANG Zhan 湯棧 把傳統火鍋做出新的樣貌
 保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。
 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。

NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂

如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。

餐點特色

NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。
此外，他們的薄餅披薩相當受歡迎，餅皮薄脆、餡料新鮮，是三五好友共享的好選擇。

用餐體驗

店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。

綜合評分

評分項目	分數（滿分5分）	評語
環境氛圍	⭐⭐⭐⭐⭐	採光好、座位寬敞，氛圍悠閒舒適
口味表現	⭐⭐⭐⭐	義式風味穩定，燉飯與披薩表現亮眼
CP值	⭐⭐⭐⭐	價位合理、份量實在
再訪意願	⭐⭐⭐⭐	適合假日早午餐或輕鬆聚會再訪

地址：40861臺中市南屯區公益路二段18號

電話：04-23288498

官網：https://nini.com.tw/

小結語

NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。
 如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。

加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇

在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。

餐點特色

主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。
我這次點的是「牛奶昆布鍋」，入口時奶香與昆布香完美融合，搭配新鮮的牛五花肉片，滑順又不膩。
菜盤走健康取向，蔬菜比例高，連玉米、南瓜、豆皮都能吃出甜味；附餐的烏龍麵Q彈有嚼勁，吃完十分有飽足感。

用餐體驗

整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。
最難得的是，即使價位不高，食材新鮮度仍維持得很好，能感受到店家對品質的堅持。

綜合評分

評分項目	分數（滿分5分）	評語
環境氛圍	⭐⭐⭐⭐	簡約乾淨、座位舒適，適合家庭聚餐
口味表現	⭐⭐⭐⭐☆	湯頭清爽細緻、奶香與昆布香交融自然
CP值	⭐⭐⭐⭐⭐	份量足、價位親民，整體表現超值
再訪意願	⭐⭐⭐⭐☆	想吃鍋又不想花太多時的首選

地址：403臺中市西區公益路288號

電話：0910855180

官網：https://giafine100.com/

小結語

加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。
如果你想在公益路找一間可以放心帶家人一起吃的鍋物店，這裡絕對會讓人感到「加分」不少。

印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選

說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。
走進印月，挑高的空間、柔和的燈光與木質桌椅構成沉穩的氛圍。
不論是家庭聚餐、商務宴客，還是節日慶祝，都能找到恰到好處的格調。

餐點特色

印月最令人印象深刻的是他們將傳統中菜融入創意手法。
這次我品嚐的「松露雞湯」香氣濃郁、層次分明，一口下去既有中式的溫潤感，又帶出西式松露的奢華香氣。
「蒜香牛肋條」則是另一道招牌菜，外酥內嫩、油香十足，咬下去肉汁在口中散開，搭配特調醬汁非常過癮。
此外，他們的創意港點如「麻辣小籠包」與「金沙流沙包」也深受年輕客群喜愛，既保留經典又玩出新意。

用餐體驗

服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。
雖然價位偏中高，但在這樣的氛圍與品質下，物有所值。

綜合評分

評分項目	分數（滿分5分）	評語
環境氛圍	⭐⭐⭐⭐⭐	典雅寬敞、氣氛沈穩，宴客首選
口味表現	⭐⭐⭐⭐⭐	每道菜都有層次與記憶點，融合創意與傳統
CP值	⭐⭐⭐⭐	價位偏高但品質穩定
再訪意願	⭐⭐⭐⭐☆	節慶或招待長輩時會再次選擇

地址：408臺中市南屯區公益路二段818號

電話：0422511155

官網：https://wein818.com/

小結語

印月餐廳是一間「不只吃飯，更像品味生活」的地方。
它成功地讓中式料理不再只是圓桌菜，而是能展現質感、講究細節的美食體驗。
若你在找一間能同時滿足味蕾與體面的餐廳，印月 絕對是公益路上的不敗經典。

KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生

若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。
隱身在公益路一隅，KoDō 的外觀低調典雅，店內以深色木質調與間接照明營造出沉穩氛圍。
從踏入店門那一刻開始，服務人員的態度、動線、聲音控制，全都精準到位，讓人彷彿走進日式劇場。

餐點特色

這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。
我點的「壽喜燒風和牛套餐」是本日最驚艷的一道——服務人員現場以鐵鍋輕煎，再淋上特製壽喜燒醬汁，香氣瞬間瀰漫整桌。
肉片油花細緻、入口即化，搭配生蛋液後更添柔滑口感。
另一道「冷藏肋眼心」則保留了和牛的彈性與甜度，每一口都能感受到油脂與炭火交織出的層次。
即使是配角如「季節小菜」與「日式和風飯」也毫不馬虎，整體呈現出高級卻不造作的平衡。

用餐體驗

KoDō 的最大特色是「儀式感」。
每位店員的動作都有節奏，從擺盤、火候、換網到講解，都像排練過無數次的演出。
在這裡用餐，會自然地放慢速度，專注於每一口肉帶來的細膩變化。
特別推薦搭配店內的紅酒或日本威士忌，風味更加圓潤。

綜合評分

評分項目	分數（滿分5分）	評語
環境氛圍	⭐⭐⭐⭐⭐	私密高雅、光線柔和，極具儀式感
口味表現	⭐⭐⭐⭐⭐	和牛品質極高、火候掌控完美
CP值	⭐⭐⭐☆	價位高，但每一口都吃得出誠意
再訪意願	⭐⭐⭐⭐☆	節慶、紀念日值得再次造訪

地址：403臺中市西區公益路260號

電話：0423220312

官網：https://www.facebook.com/kodo2018/

小結語

KoDō 和牛燒肉不是日常餐廳，而是一場體驗。
從環境、服務到食材，每個細節都讓人感受到對「完美」的執著。
若你想在公益路找一間能讓人留下深刻印象、適合紀念日慶祝的餐廳，KoDō 絕對是值得收藏的一次「味覺儀式」。

永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋

走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。
柔和的燈光灑在復古綠牆上，搭配大理石桌面與金色餐具，整體氛圍既典雅又帶有一絲文青氣息。
這裡不只是喝茶的地方，更像是把「臺灣味」以早午餐的形式重新演繹。

餐點特色

永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。
炸雞腿外酥內嫩，搭配自製酸菜與溏心蛋，鹹香中帶著層次感。
「鳳茶甜點拼盤」則以茶為靈魂——伯爵茶蛋糕、烏龍茶奶酪、紅茶雪酥，每一口都有細緻的香氣變化。
最特別的是他們的茶飲，從臺灣高山紅茶到金萱冷泡茶，每一壺都現泡現倒，香氣清雅。
對我而言，這不只是一頓飯，更是一段放鬆的午後儀式。

用餐體驗

店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。
整體氛圍很「耐坐」，許多客人吃完正餐後仍會續點一壺茶聊天。
音樂輕柔、光線柔和，是那種可以靜靜待上兩小時的地方。

綜合評分

評分項目	分數（滿分5分）	評語
環境氛圍	⭐⭐⭐⭐⭐	優雅放鬆、裝潢細緻，是拍照與休憩首選
口味表現	⭐⭐⭐⭐⭐	茶香融入料理，整體風味溫潤平衡
CP值	⭐⭐⭐⭐	餐點份量適中、價位合理
再訪意願	⭐⭐⭐⭐⭐	想放鬆、聊天、喝好茶時會立刻想到這裡

地址：40360臺中市西區公益路68號三樓(勤美誠品)

電話：0423221118

官網：https://linktr.ee/yonshin

小結語

永心鳳茶讓人重新定義「臺味」。
它不走傳統路線，而是把熟悉的元素以更細緻、更現代的方式呈現。
無論是姊妹下午茶、親子餐聚，或是想一個人沉澱片刻，永心鳳茶 都是一處能讓人慢下來、品味生活的好地方。

三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴

位於公益路上的 三希樓 是許多臺中老饕的口袋名單。
它沒有浮誇的裝潢，卻有一種低調的自信。從大門進入，就能聞到淡淡的醬香與蒸氣味，那是正宗江浙菜的靈魂。
整體裝潢以深木色為主，搭配圓桌與包廂設計，非常適合家庭聚餐或請客宴會。

餐點特色

三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。
我這次點了「東坡肉」與「蝦仁炒飯」，兩道都展現了主廚深厚的火候功力。
東坡肉油亮卻不膩，入口即化、鹹甜交織；蝦仁炒飯粒粒分明、香氣十足，每一口都吃得到鑊氣。
此外，「小籠包」皮薄多汁，是幾乎每桌必點的招牌；港點類如「金牌流沙包」與「干貝燒賣」也都表現穩定。

用餐體驗

三希樓的服務給人一種老派但貼心的感覺。
店員上菜節奏掌握得很好，會主動幫忙分菜、收盤，態度沉穩而不打擾。
最讓我印象深刻的是，這裡的客群非常多元——有帶長輩的家庭、公司聚餐，也有情侶共度節日，卻都能在同一空間裡感到自在。

綜合評分

評分項目	分數（滿分5分）	評語
環境氛圍	⭐⭐⭐⭐	傳統圓桌設計、氛圍穩重舒適
口味表現	⭐⭐⭐⭐⭐	火候精準、味道濃郁，經典不失真
CP值	⭐⭐⭐⭐	價格合理、份量足，適合多人共享
再訪意願	⭐⭐⭐⭐	家庭聚餐與宴客的安心首選

地址：408臺中市南屯區公益路二段95號

電話：0423202322

官網：https://www.sanxilou.com.tw/

小結語

三希樓是一間「吃得出功夫」的餐廳。
它不追求創新，而是用穩定的味道與真材實料，抓住每一位饕客的胃。
如果你想在公益路上找一間能兼顧長輩口味、氣氛又不拘謹的中餐廳，三希樓 絕對是最穩妥的選擇。

一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致

在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。
外觀簡約，沒有華麗招牌，只有小小的木質門面與柔黃燈光。
一推開門，迎面而來的是日式杉木香氣與寧靜的氛圍，吧檯座位整齊排列，主廚站在中間，彷彿舞臺上的演出者。

餐點特色

一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。
我這次選擇中價位套餐（約 $1200），共十多道料理，從前菜、小鉢、刺身、握壽司到甜點一氣呵成。
「比目魚鰭邊握」是整場最驚豔的瞬間——主廚以火槍輕炙，油脂瞬間釋放，入口後化成柔滑香氣。
「甜蝦海膽軍艦」則完美展現鮮度與層次感，海膽甘甜、甜蝦緊實。
搭配主廚親自調配的醬汁，每一口都像在品嚐季節的節奏。

用餐體驗

整場用餐約90分鐘，節奏緩慢但沉穩。
主廚會邊料理邊與客人互動，介紹魚種產地與食材處理方式。
雖然整體空間不大，但氣氛極佳——柔和的音樂、清酒的香氣、刀刃切魚時的聲音，讓人完全沉浸其中。
特別喜歡他們最後的甜點「焙茶奶酪」，收尾清爽優雅，為整場體驗畫下完美句點。

綜合評分

評分項目	分數（滿分5分）	評語
環境氛圍	⭐⭐⭐⭐⭐	私密安靜、燈光柔和，儀式感十足
口味表現	⭐⭐⭐⭐⭐	食材新鮮、刀工精準、層次分明
CP值	⭐⭐⭐⭐	以品質與體驗來說，價位合理
再訪意願	⭐⭐⭐⭐⭐	適合紀念日或想犒賞自己時再訪

地址：408臺中市南屯區公益路二段25號

電話：0423206368

官網：https://www.facebook.com/YIJI.sushi/

小結語

一笈壽司是一間真正讓人「放慢呼吸」的餐廳。
這裡沒有多餘擺盤，也不靠噱頭，而是以主廚對食材的尊重與技術堆疊出一場味覺饗宴。
若你想在公益路體驗日本料理最純粹的精神，一笈壽司 絕對值得你預約、靜靜期待。

茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分

若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。
不管平日或假日，用餐時段幾乎一位難求。外觀以木質格柵搭配大面玻璃設計，呈現出年輕又有質感的風格。店內空間明亮、桌距適中，播放著輕快的音樂，整體氛圍熱鬧中帶點高級感，是許多年輕人聚餐、慶生的首選地。

餐點特色

茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。
我這次點的是「厚切牛舌套餐」，肉片厚實彈牙，略帶脆感，搭配鹽蔥提味剛剛好。
另一道「和牛拼盤」也相當受歡迎，油花分布均勻、香氣濃郁，輕烤幾秒即可入口即化。
套餐附餐部分也相當用心：沙拉新鮮、味噌湯濃郁，最後還有一份「茶香冰淇淋」作結尾，香氣清爽，完美收尾。

用餐體驗

茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。
雖然客人很多，但環境維持得乾淨整潔，動線規劃良好。
最令人印象深刻的是他們的 整體節奏拿捏得剛剛好 ——餐點上桌快、氣氛熱絡，卻不會讓人覺得匆忙。
不論是朋友聚會、家庭聚餐，甚至是情侶約會，都能找到各自的樂趣。

綜合評分

評分項目	分數（滿分5分）	評語
環境氛圍	⭐⭐⭐⭐	明亮活潑、氣氛熱絡但不嘈雜
口味表現	⭐⭐⭐⭐⭐	肉質穩定、調味自然、甜點有記憶點
CP值	⭐⭐⭐⭐⭐	價格實在、份量足，是高回訪率代表
再訪意願	⭐⭐⭐⭐⭐	聚會、慶生都會再次選擇的燒肉店

地址：403臺中市西區公益路268號

電話：0423281167

官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA

小結語

茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。
不論是第一次約會還是老朋友重聚，都能在這裡找到屬於燒肉的快樂節奏。
若你在公益路只想挑一家「保證不踩雷」的燒肉店，茶六燒肉堂 絕對是首選。

吃完10家公益路餐廳後的心得與結語

吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。

有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好

有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。

而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。

這十家店，構成了公益路最動人的縮影

有華麗的，也有溫柔的；有傳統的，也有創新的。

 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。

對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。

FAQ：關於臺中公益路美食常見問題

Q1：公益路哪一區的餐廳最集中？
 最熱鬧的區段大約在「公益路與黎明路口」一帶，這裡聚集了許多知名餐廳，從高級燒肉到早午餐通通有。
像 一頭牛日式燒肉、TANG Zhan 湯棧、茶六燒肉堂 都在這附近，交通方便、停車也相對容易。

Q2：需要提前訂位嗎？
 公益路的熱門餐廳幾乎都建議 提早3～5天訂位，尤其是假日或節慶期間。
特別是 一頭牛日式燒肉、KoDō 和牛燒肉、一笈壽司 這幾家，若臨時前往幾乎很難有位。

最後的話

若要用一句話形容這趟美食之旅，我會說：
「在公益路，吃飯不是選擇，而是一種享受。」
這條路上的每一次用餐，都像一段城市裡的小旅行。
下次當你不確定想吃什麼時，不妨沿著公益路走一圈，或許下一家，正好就是你新的最愛。

三希樓有生日驚喜或畫盤嗎？

如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。茶六燒肉堂肉質如何？

無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。加分100%浜中特選昆布鍋物春酒活動適合在這裡辦嗎？

下一餐，不妨從這10家開始。KoDō 和牛燒肉長輩會喜歡嗎？

打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。TANG Zhan 湯棧年節期間價格會變嗎？

如果你有私心愛店，也歡迎留言分享，茶六燒肉堂適合辦尾牙嗎？

你的推薦，可能讓我下一趟美食旅程變得更精彩。三希樓節慶時段會不會太難訂位？

Rising sightings of invasive peach blossom jellyfish in B.C. pose ecological concerns, with climate change potentially accelerating their spread. (Peach blossom jellyfish in sample jars.) Credit: Polina Orlov Invasive peach blossom jellyfish, originating from China, have proliferated across British Columbia’s freshwater bodies, with sightings expected to escalate due to climate change. Researchers at UBC highlight that these creatures, which are clones, pose potential risks to native species by outcompeting them An invasive, freshwater jellyfish is popping up in B.C. waters in the thousands and future sightings could increase rapidly, according to UBC research. The peach blossom jellyfish clones have been spotted in 34 places in B.C., its furthest northern range in North America, and a recent paper predicts sightings and the number of locations will increase by the end of the decade as climate change extends this range. Dr. Florian Lüskow, who completed the research during his postdoctoral fellowship at UBC’s Department of Earth, Ocean and Atmospheric Sciences (EOAS), and Dr. Evgeny Pakhomov, professor in EOAS and the Institute for the Oceans and Fisheries (IOF), discuss the mysterious jelly. What do we know about these jellyfish? FL: This is an introduced jellyfish species from China that has spread around the world. We know very little about how they affect ecosystems and biodiversity of these systems in Canada, because the research hasn’t been done yet. The worry is that they harm indigenous species by outcompeting them. We’re the only researchers in Canada investigating these jellyfish, with help from citizen scientists around B.C. Peach blossom jellyfish have been reported in B.C. since 1990, mainly in the Lower Mainland, on Vancouver Island, around the Sunshine Coast, and more recently, as far inland as Osoyoos Lake. Between 1990 and 2023, a 34-year span, there have been 85 sightings, counted once per location per year, where each sighting could be one or thousands of jellyfish. But in this decade alone, we are predicting about 80 sightings, and likely in more than the 34 locations currently observed. We know that of the 100 jellyfish examined so far, each has been male and comprised of the same genetic material, which means these thousands of jellyfish are effectively clones and originated from the same polyp or a small cluster of polyps—the stage of a jellyfish which lives at the bottom of a body of water. EP: Polyps are very small, usually around a millimeter in size, and it is challenging to locate them. They inhabit shallow areas and can be found on rocks and submerged wood debris. Hence, we usually know about jellyfish introduction when we see the floating medusa form produced by polyps appear in the water, which appear only when the water temperature is higher than 21 degrees Celsius —so polyps could be in many more lakes without us knowing about it. We do not know how and when introduction of the species occurred, but it was likely through medusa-producing polyps carried on recreational boats or on the bills or feet of birds when feeding. We found medusae in ponds, quarries, and lakes, but never in creeks or rivers. And, we know that the jellyfish aren’t harmful to humans, because their stings can’t pierce human skin. How is climate change affecting these jellies? FL: B.C. is the northernmost point in this continent for the peach blossom jellyfish’s range. It relies on mild winters and high summer temperatures to reproduce, so we wouldn’t see them in the Prairies because the winters are too cold. EP: If climate change leads to freshwater temperature increases across B.C., we will likely see wider spread. Modeling indicates that even Alaskan reservoirs may potentially see invasion. However, there is a silver lining: So far only males, which are genetically identical, have been observed. This means that the jellyfish cannot complete their sexual reproduction and thus its adaptation to new environments will be limited. This would curtail their spread. What are the next steps? EP: The priority should be two-fold: first, to properly map the actual distribution of the peach blossom jellyfish, including range, in B.C. Second, to better quantify the jellyfish impact on freshwater ecosystems, including young salmon. FL: To achieve the first objective, we’d like to use environmental DNA, which is a tool that ascertains the DNA in a sample of water. This would allow us to find out if the jellyfish is present even if we can’t see it, say, in its polyp form. We’d also like to receive observations wherever they occur. People who spot a peach blossom jellyfish can submit a report to iNaturalist, the Invasive Species Council of BC, or to us. This would help us answer fundamental questions about the jellyfish and its impact on B.C. ecosystems and species, allowing better informed management recommendations. Reference: “Spatiotemporal distribution of the non-indigenous peach blossom jellyfish Craspedacusta sowerbii in British Columbia, Canada” by Florian Lüskow and Evgeny A. Pakhomov, 13 August 2024, Canadian Journal of Zoology. DOI: 10.1139/cjz-2024-0007

Groundbreaking research, analyzing eyes from various species, highlights the ancient origins and evolutionary conservation of retinal cell types. This study, revealing both cross-species similarities and species-specific adaptations, offers crucial insights for eye disease research and our understanding of vision evolution. Credit: SciTechDaily.com Though vertebrates vary widely in the number of retinal cell types, most seem to have a common origin. Karthik Shekhar and his colleagues raised a few eyebrows as they collected cow and pig eyes from Boston butchers, but those eyes — eventually from 17 separate species, including humans — are providing insights into the evolution of the vertebrate retina and could lead to better animal models for human eye diseases. The retina is a miniature computer containing diverse types of cells that collectively process visual information before transmitting it to the rest of the brain. In a comparative analysis across animals of the many cell types in the retina — mice alone have 130 types of cells in the retina, as Shekhar’s previous studies have shown — the researchers concluded that most cell types have an ancient evolutionary history. These cell types, distinguished by their differences at the molecular level, give clues to their functions and how they participate in building our visual world. Ancient Origins of Retinal Cells Their remarkable conservation across species suggests that the retina of the last common ancestor of all mammals, which roamed the Earth some 200 million years ago, must have had a complexity rivaling the retina of modern mammals. In fact, there are clear hints that some of these cell types can be traced back more than 400 million years ago to the common ancestors of all vertebrates — that is, mammals, reptiles, birds and jawed fish. The retina of vertebrate species, such as mice and humans, are remarkably conserved since the origin of jawed vertebrates more than 400 million years ago. This diagram shows the similarities between the retinal cells of humans and mice, including the ON and OFF “midget” retinal ganglion cells (MGCs). Credit: Hugo Salais, Metazoa Studio, Spain The results were published on December 13 in the journal Nature as part of a 10-paper package reporting the latest results of the BRAIN Initiative Cell Census Network’s efforts to create a cell-type atlas of the adult mouse brain. The first author is Joshua Hahn, a chemical and biomolecular engineering graduate student in Shekhar’s group at the University of California, Berkeley. The work was an equal collaboration with the group of Joshua Sanes at Harvard University. Surprising Findings in Vertebrate Vision The findings were a surprise, since vertebrate vision varies so widely from species to species. Fish need to see underwater, mice and cats require good night vision, and monkeys and humans evolved very sharp daytime eyesight for hunting and foraging. Some animals see vivid colors, while others are content with seeing the world in black and white. Yet, numerous cell types are shared across a range of vertebrate species, suggesting that the gene expression programs that define these types likely trace back to the common ancestor of jawed vertebrates, the researchers concluded. The team found, for example, that one cell type — the “midget” retinal ganglion cell — that is responsible for our ability to see fine detail, is not unique to primates, as it was thought to be. By analyzing large-scale gene expression data using statistical inference approaches, the researchers discovered evolutionary counterparts of midget cells in all other mammals, though these counterparts occurred in much smaller proportions. “What we are seeing is that something thought to be unique to primates is clearly not unique. It’s a remodeled version of a cell type that is probably very ancient,” said Shekhar, a UC Berkeley assistant professor of chemical and biomolecular engineering. “The early vertebrate retina was probably extremely sophisticated, but the parts list has been used, expanded, repurposed, or refurbished in all the species that have descended since then.” Coincidentally, one of Shekhar’s UC Berkeley colleagues, Teresa Puthussery of the School of Optometry, reported last month in Nature that another cell type thought to have been lost in the human eye — a type of retinal ganglion cell responsible for gaze stabilization — is still there. Puthussery and her colleagues used information from a previous paper co-authored by Shekhar to select molecular markers that helped identify this cell type in primate retinal tissue samples. Similarities in Vertebrate Eyes The discoveries are, in a sense, not a total surprise, since the eyes of vertebrates have a similar plan: Light is detected by photoreceptors, which relay the signal to bipolar, horizontal, and amacrine cells, which in turn connect with retinal ganglion cells, which then relay the results to the brain’s visual cortex. Shekhar uses new technologies, in particular single-cell genomics, to assay the molecular composition of thousands to tens of thousands of neurons at once within the visual system, from the retina to the visual cortex. Because the number of identified retinal cell types varies widely in vertebrates — about 70 in humans, but 130 in mice, based on previous studies by Shekhar and his colleagues — the origins of these diverse cell types were a mystery. One possibility that emerged from the new research, Shekhar said, is that as the primate brain became more complex, primates began to rely less on signal processing within the eye — which is key to reflexive actions, such as reacting to an approaching predator — and more on analysis within the visual cortex. Hence the apparent decrease in molecularly distinct cell types in the human eye. Evolution of Human Retina “Our study is saying that the human retina may have evolved to trade cell types that perform sophisticated visual computations for cell types that basically just transmit a relatively unprocessed image of the visual world with the brain so that we can do a lot more sophisticated things with that,” Shekhar said. “We are giving up speed for finesse.” Implications for Eye Disease Research The team’s new detailed map of cell types in a variety of vertebrate retinas could aid research on human eye disease. Shekhar’s group is also studying molecular hallmarks of glaucoma, the leading cause of irreversible blindness in the world and, in the U.S., the second most common cause of blindness after macular degeneration. Yet, while mice are a favorite model animal for studying glaucoma, they have very few of the midget retinal ganglion cell counterparts. These cell types make up only 2% to 4% of all ganglion cells in mice, whereas 90% of retinal ganglion cells are midget cells in humans. “This work is clinically important because, ultimately, the midget cells are probably what we should care about the most in human glaucoma,” Shekhar said. “Knowing their counterparts in the mouse will hopefully help us design and interpret these glaucoma mouse models a little better.” Single-Cell Transcriptomics in Retinal Research Shekhar and Sanes have, for the past eight years, been applying single-cell genomic approaches to profile the mRNA molecules in cells to categorize them according to their gene expression fingerprints. That technique has gradually helped identify more and more distinct cell types within the retina, many of them through studies that Shekhar initiated while a postdoctoral fellow with Aviv Regev, one of the pioneers of single-cell genomics, at the Broad Institute. It was in her lab that Shekhar began working with Sanes, a renowned retinal neurobiologist who became Shekhar’s co-advisor and collaborator. In the current study, they wanted to expand their single-cell transcriptomic approach to other species to understand how retinal cell types have changed through evolution. They gathered, in all, eyes from 17 species: human, two monkeys (macaque and marmoset), four rodents (three species of mice and one ground squirrel), three ungulates (cow, sheep and pig), tree shrew, opossum, ferret, chicken, lizard, zebrafish and lamprey. With Sanes’ team at Harvard conducting the transcriptomic experiments and Shekhar’s team at UC Berkeley conducting the computational analysis, many new cell types were identified in each of the species. They then mapped this variety to a smaller set of “orthotypes” — cell types that have likely descended from the same ancestral cell type in early vertebrates. For bipolar cells, which are a class of neurons that lie between the photoreceptors and retinal ganglion cells, they found 14 distinct orthotypes. Most extant species contain 13 to 16 bipolar types, suggesting that these types have evolved little. In contrast, they found 21 orthotypes of retinal ganglion cells, which exhibit greater variation among species. Studies thus far have identified more than 40 distinct types in mice and about 20 different types in humans. Evolutionary Divergence and Conservation Interestingly, the pronounced evolutionary divergence among types of retinal ganglion cells, as compared to other retinal classes, suggests that natural selection acts more strongly on diversifying neuron types that transmit information from the retina to the rest of the brain. They also found that numerous transcription factors, which have been implicated in retinal cell type specification in mice, are highly conserved, suggesting that the molecular steps leading to the development of the retina might be evolutionarily conserved, as well. Based on the new work, Shekhar is refocusing his glaucoma research on the analogs of midget cells, called alpha cells, in mice. Reference: “Evolution of neuronal cell classes and types in the vertebrate retina” by Joshua Hahn, Aboozar Monavarfeshani, Mu Qiao, Allison H. Kao, Yvonne Kölsch, Ayush Kumar, Vincent P. Kunze, Ashley M. Rasys, Rose Richardson, Joseph B. Wekselblatt, Herwig Baier, Robert J. Lucas, Wei Li, Markus Meister, Joshua T. Trachtenberg, Wenjun Yan, Yi-Rong Peng, Joshua R. Sanes and Karthik Shekhar, 13 December 2023, Nature. DOI: 10.1038/s41586-023-06638-9 The work was supported primarily by the National Institutes of Health (K99EY033457, R00EY028625, R21EY028633, U01MH105960, T32GM007103), the Chan-Zuckerberg Initiative (CZF-2019-002459) and the Glaucoma Research Foundation (CFC4). Shekhar also acknowledges support from the Hellman Fellows Program. Sanes was funded in part by NIH’s Brain Research Through Advancing Innovative Neurotechnologies Initiative, or the BRAIN Initiative.

Salk Institute’s groundbreaking research, as part of the BRAIN Initiative, analyzed 2 million mouse brain cells, revealing intricate details about brain cell types and gene regulation, enhancing the understanding of brain functions and disorders. (Artist’s concept.) Credit: SciTechDaily.com Researchers at Salk catalog all the chemical changes to the genetic structure that orchestrate cell behavior in the mouse brain, producing the most detailed atlas ever of the diversity and connections of neurons in the mouse brain. Salk Institute researchers, as part of a worldwide initiative to revolutionize scientists’ understanding of the brain, analyzed more than 2 million brain cells from mice to assemble the most complete atlas ever of the mouse brain. Their work, published on December 13, 2023, in a special issue of Nature, not only details the thousands of cell types present in the brain but also how those cells connect and the genes and regulatory programs that are active in each cell. The BRAIN Initiative’s Role The efforts were coordinated by the National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies® Initiative, or the BRAIN Initiative®, which ultimately aims to produce a new, dynamic picture of mammalian brains. Advancements in Brain Cell Analysis “With this work, we have not only gained a lot of information about what cells make up the mouse brain, but also how genes are regulated within those cells and how that drives the cells’ functions,” says Salk Professor, International Council Chair in Genetics, and Howard Hughes Medical Institute Investigator Joseph Ecker, who contributed to four of the new papers. “When you take this epigenome-based cell atlas and start to look at genetic variants that are known to cause human disease, you get new insight into what cell types may be most vulnerable in the disease.” The NIH BRAIN Initiative was launched in 2014 and has provided more than $3 billion in funding to researchers to develop transformative technologies and apply them to brain science. In 2021, researchers supported by the BRAIN Initiative—including teams at Salk—unveiled the first draft of the mouse brain atlas, which pioneered new tools to characterize neurons and applied those tools to small sections of the mouse brain. Earlier this year, many of the same techniques were used to assemble an initial atlas of the human brain. In the latest work, researchers expanded the number of cells studied and which areas of the mouse brain were included, as well as used new, single-cell technologies that have only emerged in the last few years. Top left: 3D rendering of anatomical mouse brain divided into sections based on brain region dissected; Bottom left: 3D rendering of mouse brain divided into multicolored segments (yellow, blue, aqua, green, pink, orange, brown, red) that represent the dissections made in each brain region.Top right: Vertical slice of mouse brain with different cell types represented by different colors (orange, green, blue, aqua, red, purple) representing the spatial location of specific cell types in that section; Bottom right: Multicolored circles (yellow, blue, aqua, green, pink, orange, brown, red) representing the amount and diversity of cell types found in the mouse whole brain based on epigenomic profiling. Credit: Salk Institute Whole Brain Analysis and Public Accessibility “This is the entire brain, which hasn’t been done before,” says Professor Edward Callaway, a senior author on two of the new papers. “There are ideas and principles that come out of looking at the whole brain that you don’t know from looking at one part at a time.” To help assist other researchers studying the mouse brain, the new data is publicly available through an online platform, which can not only be searched through a database but also queried using the artificial intelligence tool ChatGPT. “There is an incredibly large community of people who use mice as model organisms and this gives them an incredibly powerful new tool to use in their research involving the mouse brain,” adds Margarita Behrens, a Salk research professor who was involved in all four new papers. The special issue of Nature has 10 total NIH BRAIN Initiative articles, including four co-authored by Salk researchers that describe the cells of the mouse brain and their connections. Some highlights from these four papers include: Single-Cell DNA Methylation Atlas To determine all the cell types in the mouse brain, Salk researchers employed cutting-edge techniques that analyze one individual brain cell at a time. These single-cell methods studied both the three-dimensional structure of DNA inside cells and the pattern of methyl chemical groups attached to the DNA—two different ways that genes are controlled by cells. In 2019, Ecker’s lab group pioneered approaches to simultaneously make these two measurements, which lets researchers work out not only which genetic programs are activated in different cell types, but also how these programs are being switched on and off. The team found examples of genes that were activated in different cell types but through different ways—like being able to flip a light on or off with two different switches. Understanding these overlapping molecular circuits makes it easier for researchers to develop new ways of intervening in brain diseases. “If you can understand all the regulatory elements that are important in these cell types, you can also begin to understand the developmental trajectories of the cells, which becomes critical to understanding neurodevelopmental disorders like autism and schizophrenia,” says Hanqing Liu, a postdoctoral researcher in Ecker’s lab and first author of this paper. The researchers also made new discoveries about which areas of the brain contain which cell types. And when cataloguing those cell types, they additionally found that the brain stem and midbrain have far more cell types than the much larger cortex of the brain—suggesting that these smaller parts of the brain may have evolved to serve more functions. Other authors of this paper include Qiurui Zeng, Jingtian Zhou, Anna Bartlett, Bang-An Wang, Peter Berube, Wei Tian, Mia Kenworthy, Jordan Altshul, Joseph Nery, Huaming Chen, Rosa Castanon, Jacinta Lucero, Julia Osteen, Antonio Pinto-Duarte, Jasper Lee, Jon Rink, Silvia Cho, Nora Emerson, Michael Nunn, Carolyn O’Connor, and Jesse Dixon of Salk; Yang Eric Li, Songpeng Zu, and Bing Ren of UC San Diego; Zhanghao Wu and Ion Stoica of UC Berkley; Zizhen Yao, Kimberly Smith, Bosiljka Tasic, and Hongkui Zeng of the Allen Institute; and Chongyuan Luo of UC Los Angeles. Single-Cell Chromatin Maps Another way of indirectly determining the structure of DNA, and which stretches of genetic material are being actively used by cells, is testing what DNA is physically accessible to other molecules that can bind to it. Using this approach, called chromatin accessibility, researchers led by Bing Ren of UC San Diego—including Salk’s Ecker and Behrens—mapped the structure of DNA in 2.3 million individual brain cells from 117 mice. Then, the group used artificial intelligence to predict, based on those patterns of chromatin accessibility, which parts of DNA were acting as overarching regulators of the cells’ states. Many of the regulatory elements they identified were in stretches of DNA that have already been implicated in human brain diseases; the new knowledge of exactly which cell types use which regulatory elements can help pin down which cells are implicated in which diseases. Other authors of this paper include co-first authors Songpeng Zu, Yang Eric Li, and Kangli Wang of UC San Diego; Ethan Armand, Sainath Mamde, Maria Luisa Amaral, Yuelai Wang, Andre Chu, Yang Xie, Michael Miller, Jie Xu, Zhaoning Wang, Kai Zhang, Bojing Jia, Xiaomeng Hou, Lin Lin, Qian Yang, Seoyeon Lee, Bin Li, Samantha Kuan, Zihan Wang, Jingbo Shang, Allen Wang, and Sebastian Preissl of UC San Diego, Hanqing Liu, Jingtian Zhou, Antonio Pinto-Duarte, Jacinta Lucero, Julia Osteen, and Michael Nunn of Salk; and Kimberly Smith, Bosiljka Tasic, Zizhen Yao, and Hongkui Zeng of the Allen Institute. Neuron Projections and Connections In another paper, co-authored by Behrens, Callaway, and Ecker, researchers mapped connections between neurons throughout the mouse brain. Then, they analyzed how these maps compared to patterns of methylation within the cells. This let them discover which genes are responsible for guiding neurons to which areas of the brain. “We discovered certain rules dictating where a cell projects to based on their DNA methylation patterns,” says Jingtian Zhou, a postdoctoral researcher in Ecker’s lab and co-first author of the paper. The connections between neurons are critical to their function and this new set of rules may help researchers study what goes awry in diseases. Comparing Mouse, Monkey, and Human Motor Cortexes The motor cortex is the part of the mammalian brain involved in the planning and carrying out of voluntary body movements. Researchers led by Behrens, Ecker, and Ren studied the methylation patterns and DNA structure in more than 200,000 cells from the motor cortexes of humans, mice, and nonhuman primates to better understand how motor cortex cells have changed throughout human evolution. They were able to identify correlations between how particular regulatory proteins have evolved and how, in turn, the expression patterns of genes evolved. They also discovered that nearly 80 percent of the regulatory elements that are unique to humans are transposable elements—small, mobile sections of DNA that can easily change position within the genome. Summary “I think in general this whole package serves as a blueprint for other people’s future studies,” says Callaway, also the Vincent J. Coates Chair in Molecular Neurobiology at Salk. “Someone studying a particular cell type can now look at our data and see all the ways those cells connect and all the ways they’re regulated. It’s a resource that allows people to ask their own questions.” References: “Single-cell DNA methylome and 3D multi-omic atlas of the adult mouse brain” by Hanqing Liu, Qiurui Zeng, Jingtian Zhou, Anna Bartlett, Bang-An Wang, Peter Berube, Wei Tian, Mia Kenworthy, Jordan Altshul, Joseph R. Nery, Huaming Chen, Rosa G. Castanon, Songpeng Zu, Yang Eric Li, Jacinta Lucero, Julia K. Osteen, Antonio Pinto-Duarte, Jasper Lee, Jon Rink, Silvia Cho, Nora Emerson, Michael Nunn, Carolyn O’Connor, Zhanghao Wu, Ion Stoica, Zizhen Yao, Kimberly A. Smith, Bosiljka Tasic, Chongyuan Luo, Jesse R. Dixon, Hongkui Zeng, Bing Ren, M. Margarita Behrens and Joseph R. Ecker, 13 December 2023, Nature. DOI: 10.1038/s41586-023-06805-y “Single-cell analysis of chromatin accessibility in the adult mouse brain” by Songpeng Zu, Yang Eric Li, Kangli Wang, Ethan J. Armand, Sainath Mamde, Maria Luisa Amaral, Yuelai Wang, Andre Chu, Yang Xie, Michael Miller, Jie Xu, Zhaoning Wang, Kai Zhang, Bojing Jia, Xiaomeng Hou, Lin Lin, Qian Yang, Seoyeon Lee, Bin Li, Samantha Kuan, Hanqing Liu, Jingtian Zhou, Antonio Pinto-Duarte, Jacinta Lucero, Julia Osteen, Michael Nunn, Kimberly A. Smith, Bosiljka Tasic, Zizhen Yao, Hongkui Zeng, Zihan Wang, Jingbo Shang, M. Margarita Behrens, Joseph R. Ecker, Allen Wang, Sebastian Preissl and Bing Ren, 13 December 2023, Nature. DOI: 10.1038/s41586-023-06824-9 Other authors of this paper include co-first author Zhuzhu Zhang of Salk; May Wu, Hangqing Liu, Yan Pang, Anna Bartlett, Wubin Ding, Angeline Rivkin, Will Lagos, Elora Williams, Cheng-Ta Lee, Paula Assakura Miyazaki, Andrew Aldridge, Qiurui Zeng, J. L. Angelo Salida, Naomi Claffey, Michelle Liem, Conor Fitzpatrick, Lara Boggeman, Jordan Altshul, Mia Kenworthy, Cynthia Valadon, Joseph Nery, Rosa Castanon, Neelakshi Patne, Minh Vu, Mohammed Rashid, Matthew Jacobs, Tony Ito, Julia Osteen, Nora Emerson, Jasper Lee, Silvia Cho, Jon Rink, Hsiang-Hsuan Huang, António Pinto-Duarte, Bertha Dominguez, Jared Smith, Carolyn O’Connor, and Kuo-Fen Lee of Salk; Zhihao Peng of Nanchang University in China; Zizhen Yao, Kimberly Smith, Bosiljka Tasic, and Hongkui Zeng of the Allen Institute; Shengbo Chen of Henan University in China; Eran Mukamel of UC San Diego; and Xin Jin of East China Normal University in China and New York University Shanghai. “Brain-wide correspondence of neuronal epigenomics and distant projections” by Jingtian Zhou, Zhuzhu Zhang, May Wu, Hanqing Liu, Yan Pang, Anna Bartlett, Zihao Peng, Wubin Ding, Angeline Rivkin, Will N. Lagos, Elora Williams, Cheng-Ta Lee, Paula Assakura Miyazaki, Andrew Aldridge, Qiurui Zeng, J. L. Angelo Salinda, Naomi Claffey, Michelle Liem, Conor Fitzpatrick, Lara Boggeman, Zizhen Yao, Kimberly A. Smith, Bosiljka Tasic, Jordan Altshul, Mia A. Kenworthy, Cynthia Valadon, Joseph R. Nery, Rosa G. Castanon, Neelakshi S. Patne, Minh Vu, Mohammad Rashid, Matthew Jacobs, Tony Ito, Julia Osteen, Nora Emerson, Jasper Lee, Silvia Cho, Jon Rink, Hsiang-Hsuan Huang, António Pinto-Duartec, Bertha Dominguez, Jared B. Smith, Carolyn O’Connor, Hongkui Zeng, Shengbo Chen, Kuo-Fen Lee, Eran A. Mukamel, Xin Jin, M. Margarita Behrens, Joseph R. Ecker and Edward M. Callaway, 13 December 2023, Nature. DOI: 10.1038/s41586-023-06823-w “Conserved and divergent gene regulatory programs of the mammalian neocortex” by Nathan R. Zemke, Ethan J. Armand, Wenliang Wang, Seoyeon Lee, Jingtian Zhou, Yang Eric Li, Hanqing Liu, Wei Tian, Joseph R. Nery, Rosa G. Castanon, Anna Bartlett, Julia K. Osteen, Daofeng Li, Xiaoyu Zhuo, Vincent Xu, Lei Chang, Keyi Dong, Hannah S. Indralingam, Jonathan A. Rink, Yang Xie, Michael Miller, Fenna M. Krienen, Qiangge Zhang, Naz Taskin, Jonathan Ting, Guoping Feng, Steven A. McCarroll, Edward M. Callaway, Ting Wang, Ed S. Lein, M. Margarita Behrens, Joseph R. Ecker and Bing Ren, 13 December 2023, Nature. DOI: 10.1038/s41586-023-06819-6 Other authors of this paper include co-first authors Nathan Zemke and Ethan Armand of UC San Diego; Wenliang Wang, Jingtian Zhou, Hanqing Liu, Wei Tian, Joseph Nery, Rosa Castanon, Anna Bartlett, Julia Osteen, Jonathan Rink, and Edward Callaway of Salk; Seoyeon Lee, Yang Eric Li, Lei Chang, Keyi Dong, Hannah Indralingam, Yang Xie, and Michael Miller of UC San Diego; Daofeng Li, Xiaoyu Zhuo, Vincent Xu, and Ting Wang of Washington University in Missouri; Fenna Krienen of Princeton University and Harvard Medical School; Qiangge Zhang and Guoping Feng of the Broad Institute and MIT; Steven McCarroll of Harvard Medical School and the Broad Institute; and Naz Taskin, Jonathan Ting, and Ed Lein of the Allen Institute and University of Washington in Seattle. The work was supported by the National Institutes of Health BRAIN Initiative (U19MH11483, U19MH114831-04s1, 5U01MH121282, UM1HG011585, U19MH114830).

RRG455KLJIEVEWWF

 

KoDō 和牛燒肉網路評價符合期待嗎？ 》台中公益路食記攻略｜10家餐廳評分&推薦茶六燒肉堂飲料值得加點嗎？ 》公益路10家必訪餐廳｜吃貨必備指南印月餐廳家庭聚餐合適嗎？ 》公益路餐廳推薦Top10｜吃貨親訪真實心得